POS0282 PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS (JIA) ON INTENSIVE TREATMENT FREQUENTLY PRESENT ALEXITHYMIA OVER FATIGUE, ANXIETY, AND DEPRESSION, DESPITE LOW DISEASE ASSESSMENT PARAMETERS

Background Psychological factors influence quality of life, disease perception, engagement and adherence to treatment in patients with Juvenile Idiopathic Arthritis (JIA). While anxiety and/or depression have been often documented JIA, alexithymia has seldom investigated. Objectives 1.To investigate the frequency psychic symptoms JIA at a single tertiary care center, including depressive, alexithymic symptoms. 2.To correlation between demographic clinical parameters. Methods aged 8-17 years consecutively seen from March November 2022 were invited undergo psychological standardized tests: Patient Health Questionnaire-9 items (PHQ9), self-administered measure depressive symptoms; Generalised Anxiety Disorder (GAD7) test; Self-administered Psychiatric Scales for Children Adolescents anxiety-related areas (SAFA-A), depression-related (SAFA-D) somatic (SAFA-S); PedsQL™ Multidimensional Fatigue Scale; Rheumatology Module Pain Hurt; Toronto Alexithymia Scale (TAS-20); Visual Analogue (VAS) pain intensity. Demographic data, laboratory parameters assessment on same visit also recorded. Data analyzed descriptive statistics. Categorical data represented as counts percentages, while continuous means standard deviations or medians ranges. checked normality. For normally distributed appropriate parametric statistical testes employed, non non-parametric tests employed. Comparison presence/absence pain, active, painful/tender limited joints was assessed. Significant level set p<0.05. All analyses performed using R (version 4.0.3). Results Thirty-seven enrolled study: 64.9% females, 38% persistent oligoarthritis, 22% extended oligoarthritis 40% polyarthritis, 32% chronic uveitis ever. Median age 12.6 (IQR 9.3-15.3), median duration 5.5 3.6-7.6). Respectiveley, 96% 95% receiving csDMARDS bDMARDS. showed very low activity disability. PHQ9 GAD7 pathologic 41% 44%, respectively; borderline clinically scores found 27%, 29%, 13% SAFA-D, SAFA-A, SAFA-S, respectively. Of note, TAS-20 patients. No symptoms, variables features an association significant differences without VAS, active joints, joints. Conclusion In selected cohort intensive treatment, few detectable sizable proportion; higher percentage reported fatigue; even more frequent, regardless variables. Our findings support rationale adopting routine intervention patients, extending investigations their parents/guardians. References [1]Fair DC. Open Access Rheumatol 2019;11:237–52 doi: 10.2147/OARR.S174408 [2]Bano S. Cureus 12: e6807 10.7759/cureus.6807 [3]Cobham VE. J Am Acad Child Adolesc Psychiatry 2020;59:595–618 10.1016/j.jaac.2019.10.010 [4]Badarnee M. Psychol 2022;63:624-633 10.1111/sjop.12839 Acknowledgements Aurora Pucacco, HRP Division IRCCS Bambino Gesù Children’s Hospital, her logistic during study daily families. Disclosure Interests None declared.